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Voltammetric Determination of Cocaine in Confiscated Samples Using a Carbon Paste Electrode Modified with Different [UO2(X-MeOsalen)(H2O)]·H2O Complexes

2013; Multidisciplinary Digital Publishing Institute; Volume: 13; Issue: 6 Linguagem: Inglês

10.3390/s130607668

ISSN

1424-8220

Autores

Laura de Oliveira, Ana Dos Santos Poles, Marco Antônio Balbino, Matheus Teles de Menezes, José de Andrade, Edward R. Dockal, Heloísa Maria Tristão, Marcelo Firmino de Oliveira,

Tópico(s)

Analytical Methods in Pharmaceuticals

Resumo

A fast and non-destructive voltammetric method to detect cocaine in confiscated samples based on carbon paste electrode modified with methoxy-substituted N,N'-ethylene-bis(salcylideneiminato)uranyl(VI)complexes, [UO2(X-MeOSalen)(H2O)]·H2O, where X corresponds to the positions 3, 4 or 5 of the methoxy group on the aromatic ring, is described. The electrochemical behavior of the modified electrode and the electrochemical detection of cocaine were investigated using cyclic voltammetry. Using 0.1 mol·L−1 KCl as supporting-electrolyte, a concentration-dependent, well-defined peak current for cocaine at 0.62 V, with an amperometric sensitivity of 6.25 × 104 μA·mol·L−1 for cocaine concentrations ranging between 1.0 × 10−7 and 1.3 × 10−6 mol·L−1 was obtained. Chemical interference studies using lidocaine and procaine were performed. The position of the methoxy group affects the results, with the 3-methoxy derivative being the most sensitive.

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