ProfDistS: (profile-) distance based phylogeny on sequence—structure alignments
2008; Oxford University Press; Volume: 24; Issue: 20 Linguagem: Inglês
10.1093/bioinformatics/btn453
ISSN1367-4811
AutoresMatthias Wolf, Benjamin Ruderisch, Thomas Dandekar, Jörg Schultz, Tobias Müller,
Tópico(s)Machine Learning in Bioinformatics
ResumoThe Profile Neighbor Joining (PNJ) algorithm as implemented in the software ProfDist is computationally efficient in reconstructing very large trees. Besides the huge amount of sequence data the structure is important in RNA alignment analysis and phylogenetic reconstruction.For this ProfDistS provides a phylogenetic workflow that uses individual RNA secondary structures in reconstructing phylogenies based on sequence-structure alignments-using PNJ with manual or iterative and automatic profile definition. Moreover, ProfDistS can deal also with protein sequences.
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