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Phenothiazine Interference and the Porter-Silber Reaction

1968; American Association for Clinical Chemistry; Volume: 14; Issue: 2 Linguagem: Inglês

10.1093/clinchem/14.2.179

1530-8561

Aaron Lupovitch,

Phenothiazines and Benzothiazines Synthesis and Activities

Abstract Phenothiazines interfere with the Porter-Silber reaction for urinary 17, 21-dihydroxy, 20-ketosteroids. The present study suggests that the interference is a depression or inhibition of the formation of the corticosteroid bisphenylhydrazone. Slight-to-marked aberration in the color of the acidified urine extract from dark yellow to orange or pink is the clue indicating that interference is present.