Genomic Expression Discovery Predicts Pathways and Opposing Functions behind Phenotypes
2003; Elsevier BV; Volume: 278; Issue: 26 Linguagem: Inglês
10.1074/jbc.m302800200
ISSN1083-351X
AutoresHassan M. Fathallah‐Shaykh, Bin He, Li-Juan Zhao, Herbert H. Engelhard, Leonard J. Cerullo, Terry Lichtor, Richard W. Byrne, Lorenzo Muñoz, Kelvin Von Roenn, Gail Rosseau, Roberta P. Glick, Chen Sherman, Khan Farooq,
Tópico(s)Developmental Biology and Gene Regulation
ResumoDiscovering states of genetic expression that are true to a high degree of certainty is likely to predict gene function behind biological phenotypes. The states of expression (up- or down-regulated) of 19,200 cDNAs in 10 meningiomas are compared with normal brain by an algorithm that detects only 1 false measurement per 192,000; 364 genes are discovered. The expression data accurately predict activation of signaling pathways and link gene function to specific phenotypes. Meningiomas appear to acquire aberrant phenotypes by disturbing the balanced expression of molecules that promote opposing functions. The findings expose interconnected genes and propose a role of genomic expression discovery in functional genomics of living systems.
Referência(s)