Portal de Periódicos da CAPES

Artigo Acesso aberto Produção Nacional Revisado por pares

BIBTEX RIS

Functional IL‐10 Gene Polymorphism Is Associated with Chagas Disease Cardiomyopathy

2008; Oxford University Press; Volume: 199; Issue: 3 Linguagem: Inglês

10.1086/596061

1537-6613

Germano Carneiro Costa, Manoel Otávio da Costa Rocha, Paula Rocha Moreira, Cristiane Alves Silva Menezes, Micena Roberta Miranda Alves e Silva, Kenneth J. Gollob, Walderez O. Dutra,

Cardiomyopathy and Myosin Studies

This study was designed to determine whether the functional IL-10 gene polymorphism -1082G/A is associated with the development of cardiomyopathy in individuals infected with Trypanosoma cruzi and whether interleukin (IL)-10 expression can be correlated with patients' cardiac function. Our results demonstrated that the polymorphic allele, which correlates with lower expression of IL-10, was associated with the development of Chagas disease cardiomyopathy. Accordingly, correlative analysis showed that low IL-10 expression was associated with worse cardiac function, as determined by left-ventricular ejection fraction values. Therefore, the IL-10 gene polymorphism and IL-10 expression are important in determining susceptibility to chagasic cardiomyopathy.