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QT interval prolongation associated with venlafaxine administration

2005; Elsevier BV; Volume: 109; Issue: 1 Linguagem: Inglês

10.1016/j.ijcard.2005.03.065

1874-1754

Κonstantinos P. Letsas, Panagiotis Korantzopoulos, Loucas K. Pappas, Dimitrios A. Evangelou, Michalis Efremidis, Fotis Kardaras,

Ion channel regulation and function

A significant number of non-antiarrhythmic drugs including psychotropic agents have been shown to prolong cardiac repolarization increasing the risk for torsade de pointes ventricular tachycardia. We briefly describe a 60-year-old woman who admitted to the hospital due to hypertension and mild dyspnea having a prolonged QT interval (QTc: 582 ms). The patient had a known history of depression treated with venlafaxine. The QT interval normalised a few days after cessation of the antidepressant agent. This is the first report of venlafaxine-induced QT interval prolongation.