SNPLINK: multipoint linkage analysis of densely distributed SNP data incorporating automated linkage disequilibrium removal
2005; Oxford University Press; Volume: 21; Issue: 13 Linguagem: Inglês
10.1093/bioinformatics/bti449
ISSN1367-4811
AutoresEmily L. Webb, Gabrielle S. Sellick, Richard S. Houlston,
Tópico(s)RNA modifications and cancer
ResumoSummary: SNPLINK is a Perl script that performs full genome linkage analysis of high-density single nucleotide polymorphism (SNP) marker sets. The presence of linkage disequilibrium (LD) between closely spaced SNP markers can falsely inflate linkage statistics. SNPLINK removes LD from the marker sets in an automated fashion before carrying out linkage analysis. SNPLINK can compute both parametric and non-parametric statistics, utilizing the freely available Allegro and Merlin software. Graphical outputs of whole genome multipoint linkage statistics are provided allowing comparison of results before and after the removal of LD. Availability: SNPLINK is freely available for non-commercial research institutions. For full details see www.icr.ac.uk/cancgen/molgen/MolPopGen_Bioinformatics.htm Contact: richard.houlston@icr.ac.uk
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