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FGF‐4 and titanium implants: a pilot study in rabbit bone

2003; Wiley; Volume: 14; Issue: 3 Linguagem: Inglês

10.1034/j.1600-0501.2003.00846.x

1600-0501

Victoria Franke Stenport, Carina B. Johansson, Takashi Sawase, Yasuharu Yamasaki, Shinichiro Oida,

Dental Implant Techniques and Outcomes

Abstract: Aim: To evaluate the effect of a local single injection of amino‐terminally truncated recombinant human fibroblast growth factor‐4 (rhFGF‐4s) on titanium implant incorporation in a rabbit bone. Material and methods: Thirty‐six threaded titanium implants were inserted into the femur and tibia of six rabbits. Three weeks prior to implant insertion 10 μg of FGF‐4 in an altelocollagen carrier or the carrier alone was injected into the intended implant sites. Biomechanical evaluation by (i) resonance frequency analysis and (ii) peak removal torque measurements was performed after 6 weeks. The implants with surrounding tissue were processed to undecalcified ground sections followed by light‐microscopic quantifications of the bone in threaded area and the apical parts of the implants. Results: A general trend, however not statistically significant, with higher mean values obtained in the above‐mentioned tests was found. The FGF‐4‐treated implants revealed a significantly increased bone area in the apical part of the implants compared to the corresponding control implants. Conclusion: A local single injection of rhFGF‐4 may stimulate bone formation around titanium implants in bone. However, further research is required to confirm these results, understand the mechanisms of FGF, and establish optimal dose and delivery methods.