Clinical Isolates of Mycobacterium tuberculosis in Four European Hospitals Are Uniformly Susceptible to Benzothiazinones
2010; American Society for Microbiology; Volume: 54; Issue: 4 Linguagem: Inglês
10.1128/aac.01676-09
ISSN1098-6596
AutoresMaria Rosalia Pasca, Giulia Degiacomi, Ana Ribeiro, Francesca Zara, Patrizia De Mori, Béate Heym, Maurizio Mirrione, Roberto Brerra, Laura Pagani, Leopoldo Paolo Pucillo, Panajota Troupioti, Vadim Makarov, Stewart T. Cole, Giovanna Riccardi,
Tópico(s)Biochemical and Molecular Research
ResumoThe new antitubercular drug candidate 2-[2-S-methyl-1,4-dioxa-8-azaspiro[4.5]dec-8-yl]-8-nitro-6-(trifluoromethyl)-4H-1,3-benzothiazin-4-one (BTZ043) targets the DprE1 (Rv3790) subunit of the enzyme decaprenylphosphoryl-beta-d-ribose 2'-epimerase. To monitor the potential development of benzothiazinone (BTZ) resistance, a total of 240 sensitive and multidrug-resistant Mycobacterium tuberculosis clinical isolates from four European hospitals were surveyed for the presence of mutations in the dprE1 gene and for BTZ susceptibility. All 240 strains were susceptible, thus establishing the baseline prior to the introduction of BTZ043 in clinical trials.
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