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Computer-assisted karyotyping with human interaction.

1977; SAGE Publishing; Volume: 25; Issue: 7 Linguagem: Inglês

10.1177/25.7.330726

1551-5044

A. Oosterlinck, Johanna Van Den Daele, Jessica de Boer, F Dom, A. Reynaerts, Herman Van den Berghe,

Chromosomal and Genetic Variations

A system for machine assisted karyotyping and chromosome analysis has been developed. The system uses a drum- or TV-scanner as input device, runs provisionally in 32 K memory, and also allows human interaction on several stages. The accuracy with which banded chromosomes are karyotyped depends strongly on the type of classifier and varies from 40 up to 80%. The accuracy of the human assisted classifier (98%) comes close to that of a skilled technician (99.5%) using manual chromosomal analysis. Due to technical and memory limitations, the time necessary for the karyotyping of one cell is too long and depends on the interaction time; however karyotyping within 5 min, including human interaction, will be possible in the near future.