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BIBTEX RIS

CREx: inferring genomic rearrangements based on common intervals

2007; Oxford University Press; Volume: 23; Issue: 21 Linguagem: Inglês

10.1093/bioinformatics/btm468

ISSN

1367-4811

Autores

Matthias Bernt, Daniel Merkle, Kai Ramsch, Guido Fritzsch, Marleen Perseke, Detlef Bernhard, Martin Schlegel, Peter F. Stadler, Martin Middendorf,

Tópico(s)

Genomics and Phylogenetic Studies

Resumo

Abstract Summary: We present the web-based program CREx for heuristically determining pairwise rearrangement events in unichromosomal genomes. CREx considers transpositions, reverse transpositions, reversals and tandem-duplication-random-loss (TDRL) events. It supports the user in finding parsimonious rearrangement scenarios given a phylogenetic hypothesis. CREx is based on common intervals, which reflect genes that appear consecutively in several of the input gene orders. Availability: CREx is freely available at http://pacosy.informatik.uni-leipzig.de/crex Contact: merkle@informatik.uni-leipzig.de

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