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DARK MEMBRANE LYSIS AND PHOTOSENSITIZATION BY 3‐CARBETHOXYPSORALEN*

1981; Wiley; Volume: 33; Issue: 3 Linguagem: Inglês

10.1111/j.1751-1097.1981.tb05436.x

1751-1097

Renate Muller‐Runkel, Leonard I. Grossweiner,

Transgenic Plants and Applications

Abstract— Aqueous solutions of 3‐carbethoxypsoralen (3‐CPs) induce lysis of egg lecithin liposomes and whole human erythrocytes in the dark. Near‐UV irradiation of 3‐CPs sensitizes the inactivation of lysozyme attributed to the production of reactive radical intermediates. The implications of these findings for the use of 3‐CPs as a sensitizer in PUVA therapy of psoriasis are discussed.