Sexual recombination and clonal evolution of virulence in Toxoplasma
2003; Elsevier BV; Volume: 5; Issue: 7 Linguagem: Inglês
10.1016/s1286-4579(03)00088-1
ISSN1769-714X
AutoresMichael E. Grigg, Yasuhiro Suzuki,
Tópico(s)Cytomegalovirus and herpesvirus research
ResumoThe protozoan parasite Toxoplasma gondii is endemic worldwide. For such a widespread pathogen that has few geographic or host boundaries, it possess an unexpected population structure comprised principally of three clonally propagated lineages. The origin and the evolutionary dynamics of these three lines are unclear. Recent population genetic analyses suggest that a meiotic recombination between two discrete gene pools produces a pandemic outbreak of three super-successful lines, which have recently come to dominate most other strains worldwide.
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