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GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base

2010; Oxford University Press; Volume: 26; Issue: 14 Linguagem: Inglês

10.1093/bioinformatics/btq264

1367-4811

George Khelashvili, Kevin C. Dorff, Jufang Shan, Marta Camacho‐Artacho, Lucy Skrabanek, Bas Vroling, Michel Bouvier, Lakshmi A. Devi, Susan R. George, Jonathan A. Javitch, Martin J. Lohse, Graeme Milligan, Richard R. Neubig, Krzysztof Palczewski, Marc Parmentier, Jean‐Philippe Pin, Gerrit Vriend, Fabien Campagne, Marta Filizola,

Chemical Synthesis and Analysis

Abstract Summary: Rapid expansion of available data about G Protein Coupled Receptor (GPCR) dimers/oligomers over the past few years requires an effective system to organize this information electronically. Based on an ontology derived from a community dialog involving colleagues using experimental and computational methodologies, we developed the GPCR-Oligomerization Knowledge Base (GPCR-OKB). GPCR-OKB is a system that supports browsing and searching for GPCR oligomer data. Such data were manually derived from the literature. While focused on GPCR oligomers, GPCR-OKB is seamlessly connected to GPCRDB, facilitating the correlation of information about GPCR protomers and oligomers. Availability and Implementation: The GPCR-OKB web application is freely available at http://www.gpcr-okb.org Contact: marta.filizola@mssm.edu Supplementary information: Supplementary data are available at Bioinformatics online.