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Palladium‐Catalyzed Asymmetric Iodination of Unactivated CH Bonds under Mild Conditions

2005; Wiley; Volume: 44; Issue: 14 Linguagem: Inglês

10.1002/anie.200462884

1521-3773

Ramesh Giri, Xiao Chen, Jin‐Quan Yu,

Vanadium and Halogenation Chemistry

Specific, asymmetric, and mild: Oxazoline (Oxa), a removable chelating chiral auxiliary, assists in the asymmetric activation of C(sp3)H bonds at the β position and C(sp2)H bonds at the γ position. Pd(OAc)2 is an effective catalyst for the selective and asymmetric iodination of methyl, cyclopropyl, and aryl groups at room temperature (see formulae). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2005/z462884_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.