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New insights on the anticancer properties of dietary polyphenols

2006; Wiley; Volume: 26; Issue: 6 Linguagem: Inglês

10.1002/med.20060

1098-1128

Paula Fresco, Fernanda Borges, Carmen Diniz, M. Paula M. Marques,

Genomics, phytochemicals, and oxidative stress

Medicinal Research ReviewsVolume 26, Issue 6 p. 747-766 New insights on the anticancer properties of dietary polyphenols P. Fresco, Corresponding Author P. Fresco pfresco@ff.up.pt Laboratório de Farmacologia, Faculdade de Farmácia, da Universidade do Porto, PortugalLaboratório de Farmacologia, Faculdade de Farmácia, Universidade do Porto, Portugal.Search for more papers by this authorF. Borges, F. Borges Laboratório de Química Orgânica, Faculdade de Farmácia, da Universidade do Porto, Portugal Unidade “Química-Física Molecular”, Universidade de Coimbra, PortugalSearch for more papers by this authorC. Diniz, C. Diniz Laboratório de Farmacologia, Faculdade de Farmácia, da Universidade do Porto, PortugalSearch for more papers by this authorM.P.M. Marques, M.P.M. Marques Unidade “Química-Física Molecular”, Universidade de Coimbra, Portugal Departmento de Bioquímica, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, PortugalSearch for more papers by this author P. Fresco, Corresponding Author P. Fresco pfresco@ff.up.pt Laboratório de Farmacologia, Faculdade de Farmácia, da Universidade do Porto, PortugalLaboratório de Farmacologia, Faculdade de Farmácia, Universidade do Porto, Portugal.Search for more papers by this authorF. Borges, F. Borges Laboratório de Química Orgânica, Faculdade de Farmácia, da Universidade do Porto, Portugal Unidade “Química-Física Molecular”, Universidade de Coimbra, PortugalSearch for more papers by this authorC. Diniz, C. Diniz Laboratório de Farmacologia, Faculdade de Farmácia, da Universidade do Porto, PortugalSearch for more papers by this authorM.P.M. Marques, M.P.M. Marques Unidade “Química-Física Molecular”, Universidade de Coimbra, Portugal Departmento de Bioquímica, Faculdade de Ciências e Tecnologia, Universidade de Coimbra, PortugalSearch for more papers by this author First published: 18 May 2006 https://doi.org/10.1002/med.20060Citations: 372AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract Cancer, one of the major causes of death across the world, has shown to be a largely preventable disease, highly susceptible to modulation by dietary factors. Phenolic compounds, abundant in vegetables and fruits ubiquitous in diet, were described to play an important role as chemopreventive agents. Since conventional therapeutic and surgical approaches have not been able to control the incidence of most cancer types, the development of chemopreventive strategies is an urgent priority in public health. The current diet phenolic intake is often insufficient to protect from mutagens (either exogenous or endogenous), which leads to the need for dietary supplementation as an alternative approach. Research efforts are placing increasing emphasis on identifying the biological mechanisms and in particular the signal transduction pathways related to the chemopreventive activities of these compounds. These effects are believed to occur by the regulation of signaling pathways such as nuclear factor-κB (NF-κB), activator protein-1 (AP-1) or mitogen-activated protein kinases (MAPK). Dietary polyphenols can exert their effects on these pathways separately or sequentially and in addition the occurrence of crosstalk between these pathways cannot be overlooked. By modulating cell signaling pathways, polyphenols activate cell death signals and induce apoptosis in precancerous or malignant cells resulting in the inhibition of cancer development or progression. However, regulation of cell signaling pathways by dietary polyphenols can also lead to cell proliferation/survival or inflammatory responses due to increased expression of several genes. The present review summarizes the most recent advances providing new insights into the molecular mechanisms underlying the promising anticarcinogenic activity of dietary polyphenols. © 2006 Wiley Periodicals, Inc. Med Res Rev Citing Literature Volume26, Issue6November 2006Pages 747-766 RelatedInformation