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Oxygen Affinity of Hemoglobin Regulates O2Consumption, Metabolism, and Physical Activity

2003; Elsevier BV; Volume: 278; Issue: 7 Linguagem: Inglês

10.1074/jbc.m211110200

1083-351X

Takuji Shirasawa, Masahiko Izumizaki, Yo Suzuki, Akihiko Ishihara, Takahiko Shimizu, Masakatsu Tamaki, Fei Huang, Ken-ichi Koizumi, Michiko Iwase, Hiromi Sakai, Eishun Tsuchida, Kenji Ueshima, Hiroshi Inoue, Haruhiko Koseki, Toshiya Senda, Takayuki Kuriyama, Ikuo Homma,

Adipose Tissue and Metabolism

The oxygen affinity of hemoglobin is critical for gas exchange in the lung and O(2) delivery in peripheral tissues. In the present study, we generated model mice that carry low affinity hemoglobin with the Titusville mutation in the alpha-globin gene or Presbyterian mutation in the beta-globin gene. The mutant mice showed increased O(2) consumption and CO(2) production in tissue metabolism, suggesting enhanced O(2) delivery by mutant Hbs. The histology of muscle showed a phenotypical conversion from a fast glycolytic to fast oxidative type. Surprisingly, mutant mice spontaneously ran twice as far as controls despite mild anemia. The oxygen affinity of hemoglobin may control the basal level of erythropoiesis, tissue O(2) consumption, physical activity, and behavior in mice.