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The Effect of Nilvadipine, a Dihydropyridine Type Calcium Channel Blocker, on Local Cerebral Blood Flow in Rats.

1992; Japanese Pharmacological Society; Volume: 58; Issue: 4 Linguagem: Inglês

10.1254/jjp.58.457

1347-3506

Yasuhisa Furuichi, Shoji Takakura, Hisashi Satoh, Jo Mori, MASANOBU KOHSAKA,

Traumatic Brain Injury and Neurovascular Disturbances

The effect of nilvadipine, a dihydropyridine type calcium channel blocker, on local cerebral blood flow (1CBF) was investigated using the autoradiographic iodo[14C]antipyrine technique in rats. In control rats, 1CBF in cortical areas and in the superior colliculus and inferior colliculus was higher than that in the hippocampus, septal nucleus, globus pallidus and substantia nigra. Nilvadipine (32 μg/kg, i.v.) increased 1CBF in all structures (significantly in 11 of 21 structures) in spite of a 33% reduction in mean arterial blood pressure. These results confirm that nilvadipine has the ability to increase cerebral blood flow.