When Recanalization Does Not Improve Clinical Outcomes
2009; Lippincott Williams & Wilkins; Volume: 40; Issue: 8 Linguagem: Inglês
10.1161/strokeaha.109.557447
ISSN1524-4628
AutoresShelagh B. Coutts, Mayank Goyal,
Tópico(s)Cerebrovascular and Carotid Artery Diseases
ResumoHomeStrokeVol. 40, No. 8When Recanalization Does Not Improve Clinical Outcomes Free AccessEditorialPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessEditorialPDF/EPUBWhen Recanalization Does Not Improve Clinical Outcomes Shelagh B. Coutts and Mayank Goyal Shelagh B. CouttsShelagh B. Coutts From the Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region; and the Departments of Clinical Neurosciences and Radiology, University of Calgary; Calgary, Alberta, Canada. and Mayank GoyalMayank Goyal From the Seaman Family MR Research Centre, Foothills Medical Centre, Calgary Health Region; and the Departments of Clinical Neurosciences and Radiology, University of Calgary; Calgary, Alberta, Canada. Originally published9 Jul 2009https://doi.org/10.1161/STROKEAHA.109.557447Stroke. 2009;40:2661Other version(s) of this articleYou are viewing the most recent version of this article. Previous versions: July 9, 2009: Previous Version 1 See related article, pages 2761–2768.Treatment of ischemic stroke is intuitively simple with fast recanalization of blood vessels being the goal. However, this is frequently easier in theory than in practice. That is why there is some optimism in the stroke community regarding novel devices (eg, MERCI retriever system,1,2 Penumbra catheter,3 balloon angioplasty, and so on) for revascularizing intracranial vessels. The concept of the penumbra device is straightforward with clot aspiration using a vacuum pump being central to its success. The penumbra investigators describe the results of a study3 designed to meet regulatory standards assessing the use of this catheter for clot aspiration in acute stroke.The study was a prospective cohort study that enrolled 125 patients with a comparison to a historical control (the MERCI clot retriever study1). Patients were enrolled with moderate to severe ischemic stroke (National Institutes of Health Stroke Scale ≥8) within 8 hours of symptom onset. A total of 81.6% of patients had their target vessel successfully recanalized to Thrombolysis In Myocardial Infarction (TIMI) 2 to 3. However, this did not translate into improved clinical outcomes with only 25% achieving a modified Rankin Scale score of ≤2 at 90 days. This is the major unanswered question from this article: if the vessel was recanalized, why would the patient not do well? Perhaps related to this are a couple of pieces of data missing from the manuscript. First, there is no detailed description of the baseline imaging characteristics. Use of a semiquantitative scale such as the Study Group Alberta Stroke Programme Early CT Score (ASPECTS)4 may have explained the lack of clinical response in some patients.5 Second, time to recanalization is not discussed. Our personal experience is that when this device works, it works extremely well, with fast results, but this is not the case in all patients. Recanalization at a late time point with extensive early ischemic changes may in fact be harmful rather than helpful.6 The patients also appeared to have a mean delay between presentation and groin puncture of 2 hours. We wonder if there was an inverse relationship between time to puncture and likelihood of a good outcome. This is the drawback of any interventional procedure in that there is an inherent delay in getting the angiography suite mobilized. With the penumbra device, there is an opportunity to assess brain circulation and site of occlusion while the device is functioning and suction is on. It would have also been interesting to have seen data on time to clot removal once the system was in place. The authors also do not discuss in how many patients the direct thrombus removal part of the system was used. How frequently or not did investigators use this part of the system?The bottom line is that the recanalization data are promising with the penumbra catheter; however, it remains to be seen whether this translates into improved patient outcomes. Perhaps better to regard this device as another "arrow in the quiver" rather than as the whole answer. Trials such as the Interventional Management of Stroke III study,7 which compares the intra-arterial approach with the current standard of care (intravenous tissue plasminogen activator), are really important if we are to progress in our knowledge of this disease. We hope in the near future to see an efficacy study using this device that uses clinical status as the primary outcome. In the absence of such a study, readers should interpret the "high" recanalization rate with caution.The opinions expressed in this editorial are not necessarily those of the editors or of the American Heart Association.DisclosuresNone.FootnotesCorrespondence to Shelagh B. Coutts, MD, FRCPC, Department of Clinical Neurosciences, Room C1261, Foothills Medical Centre, 1403 29th Street SW, Calgary, AB, T2N 2T9, Canada. E-mail [email protected] References 1 Smith WS, Sung G, Starkman S, Saver JL, Kidwell CS, Gobin YP, Lutsep HL, Nesbit GM, Grobelny T, Rymer MM, Silverman IE, Higashida RT, Budzik RF, Marks MP; for the MERCI Investigators. Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke. 2005; 36: 1432–1438.LinkGoogle Scholar2 Smith WS, Sung G, Saver J, Budzik R, Duckwiler G, Liebeskind DS, Lutsep HL, Rymer MM, Higashida RT, Starkman S, Gobin YP; Multi MERCI investigators, Frei D, Grobelny T, Hellinger F, Huddle D, Kidwell C, Koroshetz W, Marks M, Nesbit G, Silverman IE. Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke. 2008; 39: 1205–1212.LinkGoogle Scholar3 The Penumbra Pivotal Stroke Trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease. Stroke. 2009; 40: 2761–2768.LinkGoogle Scholar4 Barber PA, Demchuk AM, Zhang J, Buchan AM. Validity and reliability of a quantitative computed tomography score in predicting outcome of hyperacute stroke before thrombolytic therapy. ASPECTS Study Group Alberta Stroke Programme Early CT Score. Lancet. 2000; 355: 1670–1674.CrossrefMedlineGoogle Scholar5 Hill MD, Rowley HA, Adler F, Eliasziw M, Furlan A, Higashida RT, Wechsler LR, Roberts HC, Dillon WP, Fischbein NJ, Firszt CM, Schulz GA, Buchan AM; PROACT-II Investigators. Selection of acute ischemic stroke patients for intra-arterial thrombolysis with pro-urokinase by using ASPECTS. Stroke. 2003; 34: 1925–1931.LinkGoogle Scholar6 Hill MD, Demchuk AM, Tomsick TA, Palesch YY, Broderick JP. Using the baseline CT scan to select acute stroke patients for IV-IA therapy. AJNR Am J Neuroradiol. 2006; 27: 1612–1616.MedlineGoogle Scholar7 Khatri P, Hill MD, Palesch YY, Spilker J, Jauch EC, Carrozzella JA, Demchuk AM, Martin R, Mauldin P, Dillon C, Ryckborst KJ, Janis S, Tomsick TA, Broderick JP. Interventional Management of Stroke III Investigators. Methodology of the Interventional Management of Stroke III trial. Int J Stroke. 2008; 3: 130–137.CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By Leinweber J, Mizurini D, Francischetti I, Fleischer M, Hermann D, Kleinschnitz C and Langhauser F (2021) Elastase inhibitor agaphelin protects from acute ischemic stroke in mice by reducing thrombosis, blood–brain barrier damage, and inflammation, Brain, Behavior, and Immunity, 10.1016/j.bbi.2020.12.027, 93, (288-298), Online publication date: 1-Mar-2021. Yeo L, Cervo A, Gopinathan A, Cunli Y, Holmberg A, Söderman M, Holmin S, Bhogal P, Gontu V, Mpotsaris A, Andersson T and Cornelissen S (2018) Very Late Leptomeningeal Collaterals—Potential New Way to Subdivide Modified Thrombolysis in Cerebral Ischemia (mTICI) 2B, Clinical Neuroradiology, 10.1007/s00062-018-0747-4, 30:1, (77-83), Online publication date: 1-Mar-2020. 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August 2009Vol 40, Issue 8 Advertisement Article InformationMetrics https://doi.org/10.1161/STROKEAHA.109.557447PMID: 19590048 Originally publishedJuly 9, 2009 KeywordsstrokeoutcomesthrombolysisPDF download Advertisement SubjectsCerebrovascular Disease/StrokeIschemic Stroke
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