Portal de Periódicos da CAPES

Role of cytokines in head and neck squamous cell carcinoma

2006; Taylor & Francis; Volume: 6; Issue: 9 Linguagem: Inglês

10.1586/14737140.6.9.1195

1744-8328

Ralph Pries, Stefan Nitsch, Barbara Wollenberg,

Cancer-related molecular mechanisms research

Head and neck squamous cell carcinoma is one of the most frequent cancers and standard treatment has only marginally improved the 5-year survival rate of patients with this disease in the last few decades. It is supposed that cytokine alterations in immune, inflammatory and angiogenetic regulatory routes within the head and neck squamous cell carcinoma microenvironment play a critical role in tumor aggressiveness, its response to chemo- and radiation therapies, as well as the development of immune escape mechanisms.