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Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations

2013; Lippincott Williams & Wilkins; Volume: 108; Issue: 11 Linguagem: Inglês

10.1038/ajg.2013.292

1572-0241

Dmitri Mouradov, Enric Domingo, Peter Gibbs, Robert N. Jorissen, Shan Li, Pik Ying Soo, Lara Lipton, Jayesh Desai, Håvard E. Danielsen, Dahmane Oukrif, Marco Novelli, Christopher Yau, Chris Holmes, Ian T. Jones, Stephen McLaughlin, Peter L. Molloy, Nicholas J. Hawkins, Robyn L. Ward, Rachel Midgely, David Kerr, Ian PM Tomlinson, Oliver M. Sieber,

Cholangiocarcinoma and Gallbladder Cancer Studies

Microsatellite instability (MSI) is an established marker of good prognosis in colorectal cancer (CRC). Chromosomal instability (CIN) is strongly negatively associated with MSI and has been shown to be a marker of poor prognosis in a small number of studies. However, a substantial group of "double-negative" (MSI-/CIN-) CRCs exists. The prognosis of these patients is unclear. Furthermore, MSI and CIN are each associated with specific molecular changes, such as mutations in KRAS and BRAF, that have been associated with prognosis. It is not known which of MSI, CIN, and the specific gene mutations are primary predictors of survival.