Syringotropic cutaneous T-cell lymphoma: an immunophenotypic and genotypic study of five cases
2004; Oxford University Press; Volume: 151; Issue: 1 Linguagem: Inglês
10.1111/j.1365-2133.2004.06028.x
ISSN1365-2133
AutoresMichael Thein, Farhana E. Ravat, Guy Orchard, Eduardo Calonje, R. Russell‐Jones,
Tópico(s)Viral-associated cancers and disorders
ResumoBritish Journal of DermatologyVolume 151, Issue 1 p. 216-226 Syringotropic cutaneous T-cell lymphoma: an immunophenotypic and genotypic study of five cases M. Thein, M. Thein Department of Dermatology, Ealing Hospital, Uxbridge Road, Southall, Middlesex UB1 3HW, U.K.Search for more papers by this authorF. Ravat, F. Ravat Department of Dermatology, Ealing Hospital, Uxbridge Road, Southall, Middlesex UB1 3HW, U.K.Search for more papers by this authorG. Orchard, G. Orchard Skin Tumour Unit, St John's Institute of Dermatology, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, U.K.Search for more papers by this authorE. Calonje, E. Calonje Skin Tumour Unit, St John's Institute of Dermatology, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, U.K.Search for more papers by this authorR. Russell-Jones, R. Russell-Jones Department of Dermatology, Ealing Hospital, Uxbridge Road, Southall, Middlesex UB1 3HW, U.K. Skin Tumour Unit, St John's Institute of Dermatology, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, U.K.Search for more papers by this author M. Thein, M. Thein Department of Dermatology, Ealing Hospital, Uxbridge Road, Southall, Middlesex UB1 3HW, U.K.Search for more papers by this authorF. Ravat, F. Ravat Department of Dermatology, Ealing Hospital, Uxbridge Road, Southall, Middlesex UB1 3HW, U.K.Search for more papers by this authorG. Orchard, G. Orchard Skin Tumour Unit, St John's Institute of Dermatology, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, U.K.Search for more papers by this authorE. Calonje, E. Calonje Skin Tumour Unit, St John's Institute of Dermatology, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, U.K.Search for more papers by this authorR. Russell-Jones, R. Russell-Jones Department of Dermatology, Ealing Hospital, Uxbridge Road, Southall, Middlesex UB1 3HW, U.K. Skin Tumour Unit, St John's Institute of Dermatology, St Thomas' Hospital, Lambeth Palace Road, London SE1 7EH, U.K.Search for more papers by this author First published: 29 June 2004 https://doi.org/10.1111/j.1365-2133.2004.06028.xCitations: 34 M.Thein. E-mail: mthein@doctors.org.uk Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Summary There is uncertainty about the exact nosological relationship between mycosis fungoides, follicular mucinosis, syringolymphoid hyperplasia with alopecia (SLHA) and syringotropic cutaneous T-cell lymphoma (CTCL). We report the clinical, histological, immunophenotypic and genotypic characteristics of a series of five patients (three men and two women) with syringotropic CTCL. We also review the 15 cases of SLHA previously reported in the literature. We conclude that syringotropic CTCL is a distinct clinicopathological variant of mycosis fungoides which may present on its own with characteristic punctate erythema or more commonly in association with folliculotropic lesions. Syringotropic CTCL is characterized histologically by infiltration of sweat glands by atypical lymphocytes in association with syringolymphoid hyperplasia. Cases of SLHA represent a syringotropic form of CTCL in association with follicular involvement, and such cases need to be investigated using T-cell receptor gene analysis of both skin and blood. Only limited conclusions on prognosis can be derived from our preliminary data. However, a review of the literature suggests that the prognosis does not differ significantly from other types of mycosis fungoides of equivalent stage. Citing Literature Volume151, Issue1July 2004Pages 216-226 RelatedInformation
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