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Risk of cancer in patients with biopsy-proven giant cell arteritis

2010; Oxford University Press; Volume: 49; Issue: 4 Linguagem: Inglês

10.1093/rheumatology/kep409

1462-0332

Catherine Hill, Aidan Cole, Maureen Rischmueller, Thomas J. Dodd, Michael Coleman, Graeme Tucker, P J Roberts-Thomson,

Otitis Media and Relapsing Polychondritis

Results of previous studies investigating the association between GCA and malignancy are conflicting. We performed a study of the risk of cancer in patients with biopsy-proven GCA.Patients with biopsy-proven GCA were identified from pathology reports of temporal artery biopsies from the major pathology laboratories in South Australia (SA). All subjects with biopsy-proven GCA were linked to the SA Cancer Registry to identify cases of cancer until 31 December 2006. Standardized incidence ratios (SIRs) for cancer were determined using the age- and gender-specific rates for SA.There were 226 cases of biopsy-proven GCA (163 females and 63 males). Thirty-one cases were diagnosed with cancer, following the diagnosis of biopsy-proven GCA. There was no increased risk of cancer among those with biopsy-proven GCA, following the diagnosis of GCA compared with the general population (SIR 1.2; 95% CI 0.8, 1.6).This cohort study did not demonstrate any increased risk for malignancy in subjects with biopsy-proven GCA.