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Viral protease inhibitors affect the production of virulence factors in Cryptococcus neoformans

2012; Canadian Science Publishing; Volume: 58; Issue: 7 Linguagem: Inglês

10.1139/w2012-075

1480-3275

José Júlio Costa Sidrim, Lauro Vieira Perdigão Neto, Rossana de Aguiar Cordeiro, Raimunda Sâmia Nogueira Brilhante, João Jaime Giffoni Leite, Carlos Eduardo Cordeiro Teixeira, A. J. Monteiro, R. Freitas, Joyce Fonteles Ribeiro, Jacó Ricarte Lima de Mesquita, Magno Gonçalves, Marcos Fábio Gadelha Rocha,

Nail Diseases and Treatments

The effects of the protease inhibitors saquinavir, darunavir, ritonavir, and indinavir on growth inhibition, protease and phospholipase activities, as well as capsule thickness of Cryptococcus neoformans were investigated. Viral protease inhibitors did not reduce fungal growth when tested in concentrations ranging from 0.001 to 1.000 mg/L. A tendency toward increasing phospholipase activity was observed with the highest tested drug concentration in a strain-specific pattern. However, these drugs reduced protease activity as well as capsule production. Our results confirm a previous finding that antiretroviral drugs affect the production of important virulence factors of C. neoformans.