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EFFECTS ON ACTH RELEASE OF INTRAPITUITARY INJECTIONS OF POSTERIOR PITUITARY HORMONES AND SEVERAL AMINES IN THE HYPOTHALAMUS

1968; Physiological Society of Japan; Volume: 18; Issue: 5 Linguagem: Inglês

10.2170/jjphysiol.18.609

1881-1396

Tsutomu Hiroshige, Haruhiko KUNITA, Chikashi OGURA, Shinji Itoh,

Growth Hormone and Insulin-like Growth Factors

By use of intrapituitary microinjection method, CRF activities of posterior pituitary hormones and several biologically active amines were examined which were reported to exist in relatively high concentrations in both the hypothalamic and the neurohypophysial tissues.It was found that none of the neurohypophysial hormones were effective at the doses used when placed directly in the adenohypophysial tissue, whereas intra-neurohypophysial injection of lysine vasopressin evoked a significant release of ACTH.These results strongly suggest that vasopressin is not CRF itself but causes ACTH release through mobilization of the neurohypophysial CRF.Among other amines examined, norepinephrine and serotonin, when injected into the anterior pituitary lobe, were devoid of CRF activity, whereas epinephrine and histamine in relatively large amounts were found potent in eliciting a significant ACTH release.These findings were discussed in relation to the possible role played by these amines in the regulation of ACTH release.