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Successful Boosting of a DNA Measles Immunization with an Oral Plant-Derived Measles Virus Vaccine

2002; American Society for Microbiology; Volume: 76; Issue: 15 Linguagem: Inglês

10.1128/jvi.76.15.7910-7912.2002

1098-5514

Diane E. Webster, Michelle L. Cooney, Zhongjun Huang, Damien R. Drew, Ian A. Ramshaw, Ian B. Dry, Richard A. Strugnell, Jenny L. Martin, Steve Wesselingh,

Plant Virus Research Studies

Despite eradication attempts, measles remains a global health concern. Here we report results that demonstrate that a single-dose DNA immunization followed by multiple boosters, delivered orally as a plant-derived vaccine, can induce significantly greater quantities of measles virus-neutralizing antibodies than immunization with either DNA or plant-derived vaccines alone. This represents the first demonstration of an enhanced immune response to a prime-boost vaccination strategy combining a DNA vaccine with edible plant technology.