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Kidney Transplantation: Mechanisms of Rejection and Acceptance

2008; Annual Reviews; Volume: 3; Issue: 1 Linguagem: Inglês

10.1146/annurev.pathmechdis.3.121806.151508

1553-4014

Lynn D. Cornell, R. Neal Smith, Robert B. Colvin,

Complement system in diseases

We describe the molecular and cellular mechanisms believed to be responsible for the rejection of renal allografts, including acute T cell-mediated rejection, acute antibody-mediated (humoral) rejection, rejection mediated by the innate immune system, and chronic rejection. We present mechanisms of graft acceptance, including accommodation, regulation, and tolerance. Studies in animals have replicated many pathologic features of acute and chronic rejection. We illuminate the pathogenesis of human pathology by reflection from experimental models.