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Transmission of Atypical Bovine Prions to Mice Transgenic for Human Prion Protein

2008; Centers for Disease Control and Prevention; Volume: 14; Issue: 12 Linguagem: Inglês

10.3201/eid1412.080941

1080-6059

Vincent Béringue, Laëtitia Herzog, Fabienne Reine, Annick Le Dur, Cristina Casalone, Jean-Luc Vilotte, Hubert Laude,

Neurological diseases and metabolism

Abstract To assess risk for cattle-to-human transmission of prions that cause uncommon forms of bovine spongiform encephalopathy (BSE), we inoculated mice expressing human PrP Met129 with field isolates. Unlike classical BSE agent, L-type prions appeared to propagate in these mice with no obvious transmission barrier. H-type prions failed to infect the mice.