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Drug Release from Compressed Hydrophilic Matrices

1968; Elsevier BV; Volume: 57; Issue: 8 Linguagem: Inglês

10.1002/jps.2600570803

1520-6017

Herbert Lapidus, Nicholas G. Lordi,

Hydrogels: synthesis, properties, applications

This study is concerned with the release of drugs from the planar surface and the whole surface of a hydrophilic polymer tablet matrix. The sustained drug-release characteristics of hydroxypropyl methylcellulose 15,000 cps. previously described was found to be the result of a hydration layer being formed at the tablet surface. As long as the integrity of the hydrated polymer was maintained, the release of drug was diffusion controlled. Environmental conditions have been investigated. Diffusion coefficients for the drugs used were calculated by means of the model equations predicting drug release from inert matrices and ointment bases. Comparison of the rates of drug release from the planar surface of a compressed polymer matrix with theoretically predicted values was made.