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BIBTEX RIS

Maternal Immunization to Modulate the Development of Allergic Response and Pathogen Infections

2008; Future Medicine; Volume: 1; Issue: 1 Linguagem: Inglês

10.2217/1750743x.1.1.141

1750-7448

Paula Ordonhez Rigato, Ana Elisa Fusaro, Jefferson Russo Victor, Maria Notomi Sato,

Vaccine Coverage and Hesitancy

This article reviews recent experimental approaches of preventive strategies regarding allergy and infections by pathogens, particularly in early childhood, by targeting maternal immunomodulation. Basic research is essential to understand maternal vaccination as a strategy to control allergic disease and bacterial and viral infections; thus, providing support for future translational research. The environmental stimuli and host genetic factors, along with maternal influences in early life when immune systems are developing and during postnatal life, are essential for the decision between tolerance induction or allergen sensitization. Maternal immunomodulation strategies should serve as a challenge when attempting to halt the spread of allergy responses and viral infections, until the innate and adaptive arms of the immune system of the neonates are competent.