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Design of Selective G-quadruplex Ligands as Potential Anticancer Agents

2008; Bentham Science Publishers; Volume: 8; Issue: 11 Linguagem: Inglês

10.2174/138955708785909880

1875-5607

Jia‐Heng Tan, Lian‐Quan Gu, Jian‐Yong Wu,

Advanced biosensing and bioanalysis techniques

G-quadruplex structures are promising targets for design of cancer drugs with high selectivity and low toxicity. This review provides an update of the progress made over the last few years in the design of selective G-quadruplex ligands, and a comprehensive summary of the major design strategies and structural characteristics. Keywords: G-quadruplex, G-quartet, ligands, substituted derivatives, affinity and selectivity, DNA interactions, telomerase inhibition