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Impact of human immunodeficiency virus infection in patients infected with the hepatitis C virus

2006; Wiley; Volume: 27; Issue: 1 Linguagem: Inglês

10.1111/j.1478-3231.2006.01344.x

1478-3231

Cristiane Valle Tovo, Ângelo Alves de Mattos, Andréa Ribeiro de Souza, Juliana Ferrari de Oliveira Rigo, Paulo Roberto Lerias de Almeida, Bruno Galperim, Breno Santos,

Hepatitis B Virus Studies

Abstract Background/Aims: The objective of the present study is to evaluate the impact of human immunodeficiency virus (HIV) in patients with hepatitis C virus (HCV) infection. Methods: Three different groups of patients were considered: group 1, 385 HCV/HIV coinfected; group 2, 198 HIV monoinfected; and group 3, 311 HCV monoinfected. Demographic and epidemiological data were collected. Blood tests included anti‐HCV, HCV‐RNA test, genotyping, CD4 cell count, anti‐HIV, and HIV viral load. Treatment with interferon and ribavirin was proposed. The fibrosis progression rate was assessed. Results: The most prevalent risk factor in the group of coinfected was the use of intravenous drugs; in the HIV monoinfection group, heterosexual relations at risk; in the HCV monoinfection group, the transfusion of blood. There was no difference concerning the distribution of genotypes or HCV viral load between groups 1 and 3. Although the mean time of duration of HCV infection was greater in group 3 than in group 1, there was no difference when the fibrosis progression rate was evaluated. The response to treatment was similar. Conclusion: In the present series there was no relevant impact of HCV infection in patients with HIV.