Portal de Periódicos da CAPES

Hepatitis B virus pre-S deletion mutations are a risk factor for hepatocellular carcinoma: a matched nested case–control study

2008; Microbiology Society; Volume: 89; Issue: 11 Linguagem: Inglês

10.1099/vir.0.2008/002824-0

1465-2099

Zhong‐Liao Fang, Caroline Sabin, Bai-qing Dong, Shao-Chao Wei, Qin-Yan Chen, Kong-Xiong Fang, Jin-ye Yang, Jian Huang, Xueyan Wang, Tim J. Harrison,

Hepatitis C virus research

A matched nested case-control study of 33 paired cases and controls was conducted, based on a study cohort in Long An county, Guangxi, China, to determine whether infection with hepatitis B virus (HBV) with pre-S deletions is independently associated with the development of hepatocellular carcinoma (HCC), without the confounding effects of basal core promoter (BCP) double mutations. The prevalence of pre-S deletions was significantly higher in HCC (45.5 %, 15 of 33) than the controls (18.2 %, 6 of 33) (P 0.05), nor was the prevalence of pre-S deletions significantly different between genotypes B and C (P>0.1). These results suggest that pre-S deletions constitute an independent risk factor for HCC and their emergence and effect are independent of BCP mutations. The 5' terminus of pre-S2 is the favoured site for the deletion mutations, especially in HCC cases. Further prospective studies are required to confirm the role of these mutations in the development of HCC.