Effect of Panretinal Photocoagulation on Retinal Blood Flow in Proliferative Diabetic Retinopathy
1986; Elsevier BV; Volume: 93; Issue: 5 Linguagem: Inglês
10.1016/s0161-6420(86)33691-1
ISSN1549-4713
AutoresJuan E. Grunwald, Charles E. Riva, Alexander J. Brucker, Stephen H. Sinclair, Benno L. Petrig,
Tópico(s)Retinal and Optic Conditions
ResumoThe effect of panretinal photocoagulation (PRP) on retinal volumetric blood flow rate and its regulatory response to hyperoxia was investigated in a main temporal vein of 15 eyes with proliferative diabetic retinopathy, using bidirectional laser Doppler velocimetry and monochromatic fundus photography. At an average of 4 ± 2 months after the beginning of PRP, retinal venous diameter decreased from an average of 174 ± 20 μm to 162 ± 19 μm (P < 0.01), red blood cell velocity decreased from 1.3 ± 0.4 cm/sec to 1.1 ± 0.4 cm/sec (P < 0.01), and blood flow decreased from 11.5 ± 3.8 μl/min to 8.4 ± 3.3 μl/min (P < 0.001). The regulatory response to hyperoxia, characterized by the percentage decrease in retinal blood flow during 100% oxygen breathing, improved from 20 ± 15% prior to treatment to 45 ± 12% following treatment (P < 0.001). The decrease in retinal blood flow is most likely due to a decrease in viable retinal tissue and an improvement in retinal oxygenation following PRP. The increase in the regulatory response to 100% O2 breathing following PRP may also result from such an improved retinal oxygenation.
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