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TFcheckpoint: a curated compendium of specific DNA-binding RNA polymerase II transcription factors

2013; Oxford University Press; Volume: 29; Issue: 19 Linguagem: Inglês

10.1093/bioinformatics/btt432

1367-4811

Konika Chawla, Sushil Tripathi, Liv Thommesen, Astrid Lægreid, Martin Kuiper,

RNA and protein synthesis mechanisms

Abstract Summary: Gene regulatory network assembly and analysis requires high-quality knowledge sources that cover functional aspects of the various components of the gene regulatory machinery. A multiplicity of resources exists with information about mammalian transcription factors (TFs); yet, only few of these provide sufficiently accurate classifications of the functional roles of individual TFs, or standardized evidence that would justify the information on which these functional classifications are based. We compiled the list of all putative TFs from nine different resources, ignored factors such as general TFs, mediator complexes and chromatin modifiers, and for the remaining factors checked the available literature for references that support their function as a true sequence-specific DNA-binding RNA polymerase II TF (DbTF). The results are available in the TFcheckpoint database, an exhaustive collection of TFs annotated according to experimental and other evidence on their function as true DbTFs. TFcheckpoint.org provides a high-quality and comprehensive knowledge source for genome-scale regulatory network studies. Availability: The TFcheckpoint database is freely available at www.tfcheckpoint.org Contact: martin.kuiper@ntnu.no Supplementary information: Supplementary data are available at Bioinformatics online.