Portal de Periódicos da CAPES

Intergenic exchange maintains identity between two human lambda light chain immunoglobulin gene intron sequences

1988; Oxford University Press; Volume: 16; Issue: 7 Linguagem: Inglês

10.1093/nar/16.7.2959

1362-4962

Jenny A. Udey, Bonnie B. Blomberg,

Endoplasmic Reticulum Stress and Disease

Evidence for gene conversion or unequal double crossover in the human lambda light chain immunoglobulin locus is presented. The high level of J2C2-J3C3 intron cross-hybridization, the identity of the J lambda and J lambda 3 coding and intron sequences, the presence of multiple base differences between the C lambda 2 and C lambda 3 coding regions, and the presence of both the unconverted and converted alleles in the normal gene pool, suggest that a recombinational event has resulted in the conversion of the J lambda 2 coding and intron sequences to those of J lambda 3 and its flanking sequences. Intergenic exchanges, such as the one described here, may provide a mechanism to maintain sequence homogeneity and functionality among the duplicated members of the human lambda gene family.