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Update on Familial Pancreatic Cancer

2010; Elsevier BV; Volume: 44; Issue: 1 Linguagem: Inglês

10.1016/j.yasu.2010.05.011

1878-0555

Ralph H. Hruban, Marcia I. Canto, Michael Goggins, Richard D. Schulick, Alison P. Klein,

Neuroendocrine Tumor Research Advances

Approximately 10% of pancreatic cancers may have a familial basis [ 1 Shi C. Hruban R.H. Klein A.P. Familial pancreatic cancer. Arch Pathol Lab Med. 2009; 133: 365-374 PubMed Google Scholar , 2 Permuth-Wey J. Egan K.M. Family history is a significant risk factor for pancreatic cancer: results from a systematic review and meta-analysis. Fam Cancer. 2009; 8: 109-117 Crossref PubMed Scopus (123) Google Scholar ]. Individuals with a family history of pancreatic cancer have an increased risk of developing pancreatic and extrapancreatic malignancies, and an individual's risk of developing pancreatic cancer can be quantified based on their family cancer history [ 1 Shi C. Hruban R.H. Klein A.P. Familial pancreatic cancer. Arch Pathol Lab Med. 2009; 133: 365-374 PubMed Google Scholar , 3 Wang W. Chen S. Brune K.A. et al. PancPRO: risk assessment in individuals with a family history of pancreatic cancer. J Clin Oncol. 2007; 25: 1417-1422 Crossref PubMed Scopus (140) Google Scholar , 4 Klein A.P. Brune K.A. Petersen G.M. et al. Prospective risk of pancreatic cancer in familial pancreatic cancer kindreds. Cancer Res. 2004; 64: 2634-2638 Crossref PubMed Scopus (448) Google Scholar ].