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Evidence for regulation of oxidative stress by latent membrane protein 1 oncoprotein in patients with low-grade leukemic B cell lymphoma with latent Epstein–Barr virus infection

2013; Taylor & Francis; Volume: 55; Issue: 8 Linguagem: Inglês

10.3109/10428194.2013.867487

1042-8194

Vasiliki Papadopoulou, Panagiotis Diamantopoulos, Elina Kontandreopoulou, Katerina Polonyfi, Eleni Variami, Panagiotis Kouzis, Athanasios Galanopoulos, Nikolaos Spanakis, Konstantinos Zervakis, Theodoros Iliakis, Δέσποινα Περρέα, Panagoula Κollia, Theodoros P. Vassilakopoulos, Gerassimos A. Pangalis, Christine Kyrtsonis, George Vaiopoulos, Nora‐Athina Viniou,

Eosinophilic Disorders and Syndromes

The role of latent Epstein-Barr virus (EBV) infection in the pathogenesis of low-grade B cell non-Hodgkin lymphoma (B-NHL) has not been studied. We therefore investigated the incidence of latent EBV infection in a group of patients with leukemic low-grade B-NHL, as well as the incidence of viral latent membrane protein 1 (LMP1) oncoprotein expression in the same patient group. Furthermore, in an attempt to elucidate the role of this viral oncoprotein in non-EBV-related lymphomas, we correlated the expression of LMP1 with the level of oxidative stress, a parameter related to apoptosis. In the present study we detected lower levels of oxidative stress in the sera of LMP1-positive patients. This possibly implies an anti-apoptotic role of this viral oncoprotein in low-grade B cell lymphomas. However, LMP1 expression status did not affect expression of the major anti-apoptotic gene BCL-2.