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Letter by Cornet et al Regarding Article, “Relationship Between Supranormal Oxygen Tension and Outcome After Resuscitation From Cardiac Arrest”

2012; Lippincott Williams & Wilkins; Volume: 125; Issue: 3 Linguagem: Inglês

10.1161/circulationaha.111.050153

1524-4539

Alexander D. Cornet, Mike J. Peters, A.J. Kooter,

Trauma and Emergency Care Studies

HomeCirculationVol. 125, No. 3Letter by Cornet et al Regarding Article, "Relationship Between Supranormal Oxygen Tension and Outcome After Resuscitation From Cardiac Arrest" Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessLetterPDF/EPUBLetter by Cornet et al Regarding Article, "Relationship Between Supranormal Oxygen Tension and Outcome After Resuscitation From Cardiac Arrest" Alexander D. Cornet, MD, Mike J. Peters, MD, PhD and Albertus J. Kooter, MD Alexander D. CornetAlexander D. Cornet Department of Internal Medicine VU University Medical Center Amsterdam, the Netherlands (Cornet, Peters, Kooter) , Mike J. PetersMike J. Peters Department of Internal Medicine VU University Medical Center Amsterdam, the Netherlands (Cornet, Peters, Kooter) and Albertus J. KooterAlbertus J. Kooter Department of Internal Medicine VU University Medical Center Amsterdam, the Netherlands (Cornet, Peters, Kooter) Originally published24 Jan 2012https://doi.org/10.1161/CIRCULATIONAHA.111.050153Circulation. 2012;125:e287To the Editor:We read with great interest the article by Kilgannon and coworkers1 demonstrating a dose-dependent linear relationship between supranormal oxygen tension after resuscitation from cardiac arrest and in-hospital death. This observation is important and merits further investigation, but we question the definition of hypoxia. The present study1 is a secondary analysis of a previously published multicenter cohort study,2 in which Project IMPACT was analyzed. A total of 6326 patients met the inclusion criteria in both studies. However, in the original analysis,2 hypoxia was defined as PaO2 <60 mm Hg or PaO2 to fraction of inspired oxygen ratio <300 mm Hg, rendering 3999 patients hypoxic. In the secondary analysis, hypoxia was defined as PaO2 <60 mm Hg or PaO2 to fraction of inspired oxygen ratio <200 mm Hg, defining 1867 patients as hypoxic. In other words, 2132 patients were "hypoxic" in the primary analysis but "normoxic" in the secondary analysis. Why did the authors use different definitions of hypoxia?Alexander D. Cornet, MDMike J. Peters, MD, PhDAlbertus J. Kooter, MD Department of Internal Medicine VU University Medical Center Amsterdam, the NetherlandsDisclosuresNone.References1. Kilgannon JH, Jones AE, Parrillo JE, Dellinger P, Milcarek B, Hunter K, Shapiro NI, Trzeciak S; Emergency Medicine Shock Research Network (EMShockNet) Investigators. Relationship between supranormal oxygen tension and outcome after resuscitation from cardiac arrest. Circulation. 2011; 123:2717–2722.LinkGoogle Scholar2. Kilgannon JH, Jones AE, Shapiro NI, Angelos MG, Milcarek B, Hunter K, Parrillo JE, Trzeciak S; Emergency Medicine Shock Research Network (EMShockNet) Investigators. Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality. JAMA. 2010; 303:2165–2171.CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetailsCited By Sjöberg F and Singer M (2013) The medical use of oxygen: a time for critical reappraisal, Journal of Internal Medicine, 10.1111/joim.12139, 274:6, (505-528), Online publication date: 1-Dec-2013. Davidescu A, Apostu S and Stanciu-Mandruleanu C (2021) Shedding Light on the Main Characteristics and Perspectives of Romanian Medicinal Oxygen Market, Healthcare, 10.3390/healthcare9020155, 9:2, (155) January 24, 2012Vol 125, Issue 3 Advertisement Article InformationMetrics © 2012 American Heart Association, Inc.https://doi.org/10.1161/CIRCULATIONAHA.111.050153PMID: 22271853 Originally publishedJanuary 24, 2012 PDF download Advertisement SubjectsCardiopulmonary Resuscitation and Emergency Cardiac Care