Anti-AIDS Agents. Part 57
2004; Elsevier BV; Volume: 14; Issue: 5 Linguagem: Inglês
10.1016/j.bmcl.2003.12.035
ISSN1464-3405
AutoresNobuko Sakurai, Jiu-Hong Wu, Yutaka Sashida, Yoshihiro Mimaki, Tamotsu Nikaido, Kazuo Koike, Hideji Itokawa, Kuo‐Hsiung Lee,
Tópico(s)Bioactive Compounds and Antitumor Agents
ResumoActein (1), a tetracyclic triterpenoid from the rhizome of Cimicifuga racemosa (black cohosh), and 82 related triterpenoid and steroidal saponins isolated from higher plants were evaluated for anti-HIV activity as a continuing study to discover potential anti-AIDS agents from natural products. Actein showed potent activity and another twelve saponins showed moderate activity. The active compounds included two steroidal, seven tetracyclic triterpenoid, and four pentacyclic triterpenoid compounds.
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