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Multicenter Analysis of Gestational Trophoblastic Neoplasia in Turkey

2014; West Asia Organization for Cancer Prevention; Volume: 15; Issue: 8 Linguagem: Inglês

10.7314/apjcp.2014.15.8.3625

2476-762X

Sabit Sinan Özalp, Elçin Telli, Tufan Öğe, Gökhan Tulunay, Nurettin Boran, Taner Turan, Müfit Cemal Yenen, Zehra Kurdoğlu, Ali Özler, K. Yüce, Volkan Ülker, Macit Arvas, Fuat Demirkıran, Tugan Beşe, Nedim Tokgözoğlu, A. Onan, Muzaffer Şancı, Mehmet Gökçü, Gökhan Tosun, Yılmaz Dikmen, Aydın Özsaran, Mustafa Coşan Terek, Levent Akman, Hakan Yetimalar, Derya Sakarya Kilic, Tayfun Güngör, Emre Özgü, Yunus Yıldız, Arif Kökçü, Mehmet Kefeli, Serkan Kuruoğlu, Hasan Yüksel, Tevfik Güvenal, Pınar Solmaz Hasdemir, Bülent Özçelik, Serdar Serin, Mehmet Dolanbay, Dağıstan Tolga Ariöz, Nadire Tuncer, Hasan Bozkaya, Süleyman Güven, Deniz Kulaksız, Füsun Varol, Yanik Ali, Gonca Ogurlu, Tayyup Şimşek, Tayfun Toptaş, Selen Doğan, Hakan Camuzoglu, Murat Apı, Kadir Güzin, Caliskan Eray, Emek Döğer,

Ectopic Pregnancy Diagnosis and Management

To evaluate the incidence, diagnosis and management of GTN among 28 centers in Turkey.A retrospective study was designed to include GTN patients attending 28 centers in the 10-year period between January 2003 and May 2013. Demographical characteristics of the patients, histopathological diagnosis, the International Federation of Gynecology and Obstetrics (FIGO) anatomical and prognostic scores, use of single-agent and multi-agent chemotherapy, surgical interventions and prognosis were evaluated.From 2003-2013, there were 1,173,235 deliveries and 456 GTN cases at the 28 centers. The incidence was calculated to be 0.38 per 1,000 deliveries. According to the evaluated data of 364 patients, the median age at diagnosis was 31 years (range, 15-59 years). A histopathological diagnosis was present for 45.1% of the patients, and invasive mole, choriocarcinoma and PSTTs were diagnosed in 22.3% (n=81), 18.1% (n=66) and 4.7% (n=17) of the patients, respectively. Regarding final prognosis, 352 (96.7%) of the patients had remission, and 7 (1.9%) had persistence, whereas the disease was mortal for 5 (1.4%) of the patients.Because of the differences between countries, it is important to provide national registration systems and special clinics for the accurate diagnosis and treatment of GTN.