MicroRNA precursors in motion: exportin-5 mediates their nuclear export
2004; Elsevier BV; Volume: 14; Issue: 4 Linguagem: Inglês
10.1016/j.tcb.2004.02.006
ISSN1879-3088
Autores Tópico(s)RNA Interference and Gene Delivery
ResumoThe discovery of microRNSs (miRNAs) has changed the paradigm of gene regulation, leaving us with numerous exciting questions regarding what these molecules do and how they originate. A model for miRNA biogenesis has emerged recently, yet several key factors--including the identity of the miRNA nuclear export receptor--remained unknown. However, recent studies have shown that exportin-5 (Exp5), a Ran-dependent importin-beta-related transport receptor, mediates nuclear export of miRNA precursors (pre-miRNAs).
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