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Association of the IFNL4-ΔG Allele With Impaired Spontaneous Clearance of Hepatitis C Virus

2013; Oxford University Press; Volume: 209; Issue: 3 Linguagem: Inglês

10.1093/infdis/jit433

1537-6613

Peter Aka, Mark H. Kuniholm, Ruth M. Pfeiffer, Alan S. Wang, Wei Tang, Sabrina Chen, Jacquie Astemborski, Michael Plankey, Maria C. Villacres, Marion G. Peters, Seema Desai, Eric C. Seaberg, Brian R. Edlin, Howard D. Strickler, David L. Thomas, Ludmila Prokunina‐Olsson, Gerald B. Sharp, Thomas R. OʼBrien,

Hepatitis B Virus Studies

Interferon lambda 4 protein can be generated in IFNL4-ΔG carriers but not IFNL4-TT homozygotes. We studied 890 anti–hepatitis C virus (HCV)–positive participants in the Women's Interagency HIV Study. Among blacks (n = 555), HCV was more often cleared for those with genotype IFNL4-TT/TT (32.6%; odds ratio [OR], 3.59; P = 3.3 × 10−5) than IFNL4-TT/ΔG (11.3%; OR, 0.95; P = .86) or IFNL4-ΔG/ΔG (11.9%; referent). Pooling these data with published results in blacks (n = 1678), ORs were 3.84 (P = 8.6 × 10−14) for IFNL4-TT/TT and 1.44 (P = .03) IFNL4-TT/ΔG, and the area under the curve was 0.64 for IFNL4-ΔG genotype and 0.61 for rs12979860 (IL28B). IFNL4-ΔG is strongly associated with impaired spontaneous HCV clearance.