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Polymer Nanofiber‐Embedded Microchips for Detection, Isolation, and Molecular Analysis of Single Circulating Melanoma Cells

2013; Wiley; Volume: 52; Issue: 12 Linguagem: Inglês

10.1002/anie.201208452

1521-3773

Shuang Hou, Libo Zhao, Qinglin Shen, Juehua Yu, Charles Wang Wai Ng, Xiangju Kong, Dongxia Wu, Min Song, Xiaohong Shi, Xiaochun Xu, Wei‐Han OuYang, Rongxian He, Xingzhong Zhao, Tom Lee, F. Charles Brunicardi, Mitch A. Garcia, Antoni Ribas, Roger S. Lo, Hsian‐Rong Tseng,

Immunotherapy and Immune Responses

Confined to one cell: A method to detect and isolate single circulating melanoma cells (CMCs; see figure) has been produced by integrating a polymer-nanofiber-embedded nanovelcro cell-affinity assay with a laser microdissection (LMD) technique. This method is able to separate CMCs from normal white blood cells (WBCs) and sequence individual cells for a specific mutation related to cancer progression, allowing for more personalized cancer therapy. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.