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Novel Bladder Preservation Therapy with Osaka Medical College Regimen

2014; Lippincott Williams & Wilkins; Volume: 193; Issue: 2 Linguagem: Inglês

10.1016/j.juro.2014.08.094

1527-3792

Haruhito Azuma, Teruo Inamoto, Kiyoshi Takahara, Hayahito Nomi, Hajime Hirano, Naokazu Ibuki, Hiroshi Uehara, Kazumasa Komura, Koichiro Minami, Taizo Uchimoto, Kenkichi Saito, Tomoaki Takai, Naoki Tanda, Kazuhiro Yamamoto, Y Narumi, Satoshi Kiyama,

Urinary Bladder and Prostate Research

No AccessJournal of UrologyAdult Urology1 Feb 2015Novel Bladder Preservation Therapy with Osaka Medical College Regimen Haruhito Azuma, Teruo Inamoto, Kiyoshi Takahara, Hayahito Nomi, Hajime Hirano, Naokazu Ibuki, Hiroshi Uehara, Kazumasa Komura, Koichiro Minami, Taizo Uchimoto, Kenkichi Saito, Tomoaki Takai, Naoki Tanda, Kazuhiro Yamamoto, Yoshihumi Narumi, and Satoshi Kiyama Haruhito AzumaHaruhito Azuma Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan , Teruo InamotoTeruo Inamoto Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan , Kiyoshi TakaharaKiyoshi Takahara Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan , Hayahito NomiHayahito Nomi Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan , Hajime HiranoHajime Hirano Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan , Naokazu IbukiNaokazu Ibuki Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan , Hiroshi UeharaHiroshi Uehara Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan , Kazumasa KomuraKazumasa Komura Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan , Koichiro MinamiKoichiro Minami Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan , Taizo UchimotoTaizo Uchimoto Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan , Kenkichi SaitoKenkichi Saito Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan , Tomoaki TakaiTomoaki Takai Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan , Naoki TandaNaoki Tanda Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan , Kazuhiro YamamotoKazuhiro Yamamoto Department of Radiology, Osaka Medical College, Takatsuki, Osaka, Japan , Yoshihumi NarumiYoshihumi Narumi Department of Radiology, Osaka Medical College, Takatsuki, Osaka, Japan , and Satoshi KiyamaSatoshi Kiyama Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan View All Author Informationhttps://doi.org/10.1016/j.juro.2014.08.094AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We investigated the effect of balloon occluded arterial infusion of an anticancer agent (cisplatin/gemcitabine), used concomitantly with hemodialysis, which delivers an extremely high concentration of anticancer agent to the tumor site without systemic adverse effects, along with concurrent radiation (referred to as the Osaka Medical College regimen) in patients with advanced bladder cancer. Materials and Methods: A total of 329 patients (TisN0 16, T2N0 174, T3N0 77, T4N0 22 and TxN+ 40) were assigned to receive the Osaka Medical College regimen. Patients who did not achieve complete response underwent total cystectomy or secondary balloon occluded arterial infusion with an increased amount of cisplatin and/or gemcitabine. Results: The Osaka Medical College regimen allowed 83.6% (276 of 329) of patients in total and 93.6% (250 of 267) of patients with organ confined disease (including T3b) to achieve complete response. Of the patients with a complete response 96% (240 of 250) survived with a functional bladder without evidence of recurrent disease within a mean followup of 159 weeks. Although lymph node involvement, especially N2 stage, was selected as a significant risk factor for treatment failure and survival, it was noteworthy that 61.9% of patients with N1 disease achieved complete response and that the 5-year overall survival rate was 72.2%. 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Google Scholar © 2015 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byDreicer R (2014) Interdisciplinary Management of Locally Advanced and Metastatic Genitourinary Cancers: A Team SportJournal of Urology, VOL. 193, NO. 2, (389-390), Online publication date: 1-Feb-2015.Steers W (2014) This Month in Adult UrologyJournal of Urology, VOL. 193, NO. 2, (383-384), Online publication date: 1-Feb-2015. Volume 193Issue 2February 2015Page: 443-450Supplementary Materials Advertisement Copyright & Permissions© 2015 by American Urological Association Education and Research, Inc.Keywordsballoon occlusionhemodialysis solutionsinfusionsintra-arterialurinary bladder neoplasmsMetricsAuthor Information Haruhito Azuma Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan Equal study contribution. More articles by this author Teruo Inamoto Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan Equal study contribution. More articles by this author Kiyoshi Takahara Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan Equal study contribution. More articles by this author Hayahito Nomi Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan More articles by this author Hajime Hirano Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan More articles by this author Naokazu Ibuki Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan More articles by this author Hiroshi Uehara Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan More articles by this author Kazumasa Komura Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan More articles by this author Koichiro Minami Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan More articles by this author Taizo Uchimoto Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan More articles by this author Kenkichi Saito Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan More articles by this author Tomoaki Takai Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan More articles by this author Naoki Tanda Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan More articles by this author Kazuhiro Yamamoto Department of Radiology, Osaka Medical College, Takatsuki, Osaka, Japan More articles by this author Yoshihumi Narumi Department of Radiology, Osaka Medical College, Takatsuki, Osaka, Japan More articles by this author Satoshi Kiyama Department of Urology, Osaka Medical College, Takatsuki, Osaka, Japan More articles by this author Expand All Advertisement PDF downloadLoading ...