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Comparison the Prognostic Value of Galectin-3 and Serum Markers of Cardiac Extracellular Matrix Turnover in Patients with Chronic Systolic Heart Failure

2014; Ivyspring International Publisher; Volume: 11; Issue: 11 Linguagem: Inglês

10.7150/ijms.8083

1449-1907

Yi‐Yao Chang, Aaron Chen, Xue-Ming Wu, Tse‐Pin Hsu, Liyu Liu, Yenh-Hsein Chen, Yen‐Wen Wu, Hung‐Ju Lin, Ron‐Bin Hsu, Chi‐Ming Lee, Shoei‐Shen Wang, Men‐Tzung Lo, Ming-Fong Chen, Yen‐Hung Lin,

Magnesium Alloys: Properties and Applications

Background: shows the ability of survival prediction in heart failure (HF) patients.However, Gal-3 is strongly associated with serum markers of cardiac extracellular matrix (ECM) turnover.The aim of this study is to compare the impact of Gal-3 and serum markers of cardiac ECM turnover on prognostic prediction of chronic systolic HF patients.Methods: Serum Gal-3, brain natriuretic peptide (BNP), extracellular matrix including type I and III aminoterminal propeptide of procollagen (PINP and PIIINP), matrix metalloproteinase-2, 9 (MMP-2, 9), and tissue inhibitor of metalloproteinase-1 (TIMP-1) were analyzed.Cox regression analysis was used for survival analysis.Results: A total of 105 (81 male) patients were enrolled.During 980±346 days follow-up, 17 patients died and 36 episodes of HF admission happened.Mortality of these patients was significantly associated with the log PIIINP (β= 15.380; P=0.042), log TIMP-1(β= 44.530; P=0.003), log MMP-2 (β= 554.336;P<0.001), log BNP (β= 28.273; P=0.034).Log Gal-3 (β= 7.484; P=0.066) is borderline associated with mortality.Mortality or first HF admission of these patients was significantly associated with the log TIMP-1(β= 16.496; P=0.006), log MMP-2 (β= 221.864;P<0.001), log BNP (β= 5.999; P=0.034).Log Gal-3 (β= 4.486; P=0.095)only showed borderline significance.In several models adjusting clinical parameters, log MMP-2 was significantly associated with clinical outcome.In contrast, log Gal-3 was not. Conclusion:The prognostic strength of MMP-2 to clinical outcome prediction in HF patients is stronger than Gal-3.