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Reversible Cell‐Specific Drug Delivery with Aptamer‐Functionalized Liposomes

2009; Wiley; Volume: 48; Issue: 35 Linguagem: Inglês

10.1002/anie.200901452

1521-3773

Zehui Cao, Rong Tong, Abhijit Mishra, Weichen Xu, Gerard C. L. Wong, Jianjun Cheng, Yi Lu,

DNA and Nucleic Acid Chemistry

Aptamer advantages: Cell-specific delivery of the anticancer drug cisplatin through a nucleolin-aptamer-conjugated, cisplatin-encapsulating liposome delivery system is described. Calcein was incorporated into the target MCF-7 cells (see top image) but not into LNCaP cells (see bottom image). More importantly, the extent of delivery can be controlled by using a complementary DNA of the aptamer as an antidote. Detailed facts of importance to specialist readers are published as "Supporting Information". Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.