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Integrating Genetic, Transcriptional, and Functional Analyses to Identify 5 Novel Genes for Atrial Fibrillation

2014; Lippincott Williams & Wilkins; Volume: 130; Issue: 15 Linguagem: Inglês

10.1161/circulationaha.114.009892

1524-4539

Moritz F. Sinner, Nathan R. Tucker, Kathryn L. Lunetta, Kouichi Ozaki, J. G. Smith, Stella Trompet, Joshua C. Bis, Honghuang Lin, Mina K. Chung, Jonas B. Nielsen, Steven A. Lubitz, Bouwe P. Krijthe, Jared W. Magnani, Jiangchuan Ye, Michael H. Gollob, Tatsuhiko Tsunoda, Martina Müller‐Nurasyid, Peter Lichtner, Annette Peters, Elena Dolmatova, Michiaki Kubo, Jonathan D. Smith, Bruce M. Psaty, Nicholas L. Smith, J. Wouter Jukema, Daniel I. Chasman, Christine M. Albert, Yusuke Ebana, Tetsushi Furukawa, Peter W. Macfarlane, Tamara B. Harris, Dawood Darbar, Marcus Dörr, Anders G. Holst, Jesper Hastrup Svendsen, Albert Hofman, André G. Uitterlinden, Vilmundur Guðnason, Mitsuaki Isobe, Rainer Malik, Martin Dichgans, Jonathan Rosand, David R. Van Wagoner, Emelia J. Benjamin, David J. Milan, Olle Melander, Susan R. Heckbert, Ian Ford, Yongmei Liu, John Barnard, Morten S. Olesen, Bruno H. Stricker, Toshihiro Tanaka, Stefan Kääb, Patrick T. Ellinor,

Atrial Fibrillation Management and Outcomes

Atrial fibrillation (AF) affects >30 million individuals worldwide and is associated with an increased risk of stroke, heart failure, and death. AF is highly heritable, yet the genetic basis for the arrhythmia remains incompletely understood.