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Low CYP1A2 activity in rural Shona children of Zimbabwe*

1995; Wiley; Volume: 57; Issue: 1 Linguagem: Inglês

10.1016/0009-9236(95)90262-7

1532-6535

Collen Masimirembwa, Mayra Beke, Julia A. Hasler, Bing-Kou Tang, W. Kalow,

Drug-Induced Hepatotoxicity and Protection

Clinical Pharmacology & TherapeuticsVolume 57, Issue 1 p. 25-31 Pharmacokinetics and Drug Disposition Low CYP1A2 activity in rural Shona children of Zimbabwe Collen M. Masimirembwa BSc, Collen M. Masimirembwa BSc Department of Biochemistry, University of Zimbabwe, Harare, Zimbabwe Department of Pharmacology, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorMayra Beke MSc, Mayra Beke MSc Department of Biochemistry, University of Zimbabwe, Harare, Zimbabwe Department of Pharmacology, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorJulia A. Hasler PhD, Julia A. Hasler PhD Department of Biochemistry, University of Zimbabwe, Harare, Zimbabwe Department of Pharmacology, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorBing-Kou Tang PhD, Bing-Kou Tang PhD Department of Biochemistry, University of Zimbabwe, Harare, Zimbabwe Department of Pharmacology, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorWerner Kalow MD, Corresponding Author Werner Kalow MD Department of Biochemistry, University of Zimbabwe, Harare, Zimbabwe Department of Pharmacology, University of Toronto, Toronto, Ontario, CanadaWerner Kalow, MD, Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada.Search for more papers by this author Collen M. Masimirembwa BSc, Collen M. Masimirembwa BSc Department of Biochemistry, University of Zimbabwe, Harare, Zimbabwe Department of Pharmacology, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorMayra Beke MSc, Mayra Beke MSc Department of Biochemistry, University of Zimbabwe, Harare, Zimbabwe Department of Pharmacology, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorJulia A. Hasler PhD, Julia A. Hasler PhD Department of Biochemistry, University of Zimbabwe, Harare, Zimbabwe Department of Pharmacology, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorBing-Kou Tang PhD, Bing-Kou Tang PhD Department of Biochemistry, University of Zimbabwe, Harare, Zimbabwe Department of Pharmacology, University of Toronto, Toronto, Ontario, CanadaSearch for more papers by this authorWerner Kalow MD, Corresponding Author Werner Kalow MD Department of Biochemistry, University of Zimbabwe, Harare, Zimbabwe Department of Pharmacology, University of Toronto, Toronto, Ontario, CanadaWerner Kalow, MD, Department of Pharmacology, Medical Sciences Building, University of Toronto, Toronto, Ontario M5S 1A8, Canada.Search for more papers by this author First published: January 1995 https://doi.org/10.1016/0009-9236(95)90262-7Citations: 2AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Abstract Caffeine is increasingly used as a biochemical probe for liver function, in cancer epidemiology, and in pharmacogenetics, with its recognized ability to assess the activities of CYP1A2, xanthine oxidase, and N-acetyltransferase-2. The activity of these hepatic enzymes was tested in 45 Shona children from a rural area of Zimbabwe with use of caffeine as a probe. Many of these rural black children had lower indexes of CYP1A2 activity than otherwise on our extensive records; the average value (3.78 ± 2.9) was significantly (p < 0.001) lower than that of healthy white urban children from Zimbabwe (8.86 ± 3.36) or from Canada (7.92 ± 1.88), or that of healthy Canadian adults (5.96 ± 2.4). A higher CYP1A2 activity in children than in adults is usual. The low CYP1A2 activity of the children from rural Zimbabwe calls for medical studies and suggests a widespread and perhaps serious impairment of certain liver functions. Causes could be parasitic infections with Schistosoma mansoni, causing schistosomiasis, which are endemic, in addition to generally poor nutrition and frequent iodine deficiency. By contrast, the xanthine oxidase activity in rural Shona children was slightly higher than that reported for a healthy Canadian adult population. The N-acetyltransferase activities were comparable in both the rural and urban children and were also similar to those reported in a population study of healthy adult Canadians. Clinical Pharmacology & Therapeutics (1995) 57, 25–31; doi: Citing Literature Volume57, Issue1January 1995Pages 25-31 RelatedInformation