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Inhibition of Theophylline Elimination by Diltiazem Therapy

1987; Wiley; Volume: 27; Issue: 11 Linguagem: Inglês

10.1002/j.1552-4604.1987.tb05580.x

1552-4604

Anne N. Nafziger, John J. May, Joseph Bertino,

Poisoning and overdose treatments

To investigate the effects of diltiazem on theophylline pharmacokinetics, nine healthy male subjects (four smokers and five nonsmokers) received intravenous aminophylline (6 mg/kg) prior to and following 10 days of oral diltiazem therapy. Theophylline half‐life increased significantly whereas total body clearance showed a significant decrease following diltiazem. Volume of distribution was unchanged. The small group of smokers had a significantly greater increase in theophylline half‐life than the nonsmokers. Inhibition of metabolism of theophylline by diltiazem likely explains the significant changes in theophylline pharmacokinetics. A clinically important drug interaction may occur with theophylline when diltiazem therapy is given concurrently.